Research

The work behind the platform.

We spent years building this technology in the lab, InstaNovo and the ecosystem that grew out of it, before bringing it to companies and researchers.

Publications

Nature Communications

2026

InstaNovo-P: a de novo peptide sequencing model for phosphoproteomics

Extends de novo sequencing to phosphorylated peptides, one of the modification-heavy settings where database-driven interpretation loses the most ground.

Read the paper

Molecular & Cellular Proteomics

2026

Generalizable direct protein sequencing with InstaNexus

An end-to-end approach to reading full proteins that lack a genomic reference, the case that matters most for antibodies, venoms and engineered sequences.

Read the paper

arXiv

2025 · Preprint

De novo peptide sequencing rescoring and FDR estimation with Winnow

The confidence layer: rescoring de novo predictions and estimating false discovery rates, so results can be filtered at a threshold that means something.

Read the preprint

Nature Machine Intelligence

2025

InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments

Introduces the transformer and diffusion-based de novo sequencing models at the core of the platform, and demonstrates peptide identification at the scale of real proteomics experiments without a reference database.

Read the paper

Read it, then test it

If you want to run Seqora against your own data, or talk through any of this in detail, get in touch.